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During 2015–2018, an estimated 1.6 million U.S. adults aged ≥18 years, on average, reported past-year methamphetamine use; 52.9% had a methamphetamine use disorder, and 22.3% reported injecting methamphetamine within the …

Heavy METH use has toxic effects on the brain, mainly on the nigrostriatal dopamine pathway, that are mediated by oxidative stress, inflammation and excitotoxicity 19. People who abuse METH heavily …